About
AlphaPerrin Computational ™
About AlphaPerrin Computational:
AlphaPerrin Computational is a leading technology company transforming the field of computational chemistry. Our core mission is to empower students of all levels, academics, drug developers, pathologists, university researchers, and professionals as they pursue breakthroughs in disease treatment. Providing cutting-edge technology to everyone, in a suite of services tailored to meet our clients’ diverse needs.
Our computational chemistry platform is a powerful tool accessible to all. Primarily designed to accelerate drug discovery, it offers a versatile foundation for academic and industrial research. Its applications span a wide range, from developing new therapeutics in molecular biology to exploring fundamental scientific questions. Currently, our platform is being utilized in groundbreaking research focused on diseases such as Lyme, Alzheimer’s, and cancer.
At the core of our operations are high-powered computers running Gaussian, Inc.’s Computational Chemistry software—the gold standard for molecular structure calculations. These robust systems enable you to execute complex calculations with exceptional efficiency and precision.
Our methodology involves conducting various calculations to pinpoint the lowest energy conformer for the drug or pro-drug under development.
These calculations may range from several days to mere hours, depending on the complexity of the task. Once the lowest energy conformer is identified, clients will have a solid baseline molecule design ready for environmental testing.
We provide CPU time on our servers for clients to conduct their own Gaussian experiments without any restrictions on CPU hours or contractual obligations. To safeguard our client’s data with the utmost security and confidentiality, we offer non-disclosure agreements as part of our comprehensive service package.
Data security is a top priority for us. That’s why we utilize both securely stored onsite backups and cloud backups with multiple redundancies to ensure the safety of our client’s valuable data. Recognizing the unique nature of each project, we offer simple pricing packages and storage solutions so you can focus on what is most important: your research.
For further questions or want to get started, please contact one of our knowledgeable agents. At AlphaPerrin Computational™, we are dedicated to empowering you to develop innovative solutions that advance drug discovery and disease research.
Our Mission
In the realm of pharmaceutical research, numerous small and medium-sized commercial and university drug labs tirelessly engage in drug discovery and disease studies.
At AlphaPerrin Computational™, we empathize with the prevalent challenge faced by these labs: the exorbitant costs and time constraints associated with traditional “wet” lab procedures. To address this issue, we present an alternative solution—a groundbreaking platform rooted in Computational Chemistry. AlphaPerrin Computational offers a more accessible and cost-effective avenue toward achieving experimental objectives. Through our platform, labs can conduct simulations and analyze drug interactions and molecular structures via computer workups, markedly reducing the reliance on costly and resource-intensive laboratory experiments.
Our innovative tool streamlines the research process and unlocks avenues for creative solutions previously beyond reach for individual researchers and smaller organizations. Embracing this cutting-edge technology, labs embark on a journey of exploration, forging paths toward novel breakthroughs and advancements in pharmaceutical science and drug discovery.
Our Story
Our story is an intriguing one. As a graduate student, my work focused on estrogen-related cancers. There was one interesting problem, however: the mechanism of binding of the estrogen molecule to the estrogen receptor had not been fully understood. Through numerous binding experiments using fluorescence correlation spectroscopy, I, too, found that for estrogen to bind to its receptor, another protein called a steroid receptor co-activator was required.
Upon completing my dissertation, I accepted a position within the UNC system as a chemistry professor, teaching biochemistry, biophysics, and general chemistry. My lab work revealed a more efficient way to determine binding computationally. I wrote a grant for computer servers and nodes and began working with Gaussian, drawing on my background with undergraduate degrees in chemistry and biology and a master’s degree in chemistry. This computational approach was significantly more cost-effective than ordering materials for in vitro chemistry.
After fifteen years as a college professor, an unfortunate accident required me to take a few years off to recuperate. During this time, I contemplated how I could return to estrogen cancer research using in silico methods.
Coincidentally, my dear friend contracted Lyme disease, a debilitating condition affecting various bodily systems, including the immune system. In an effort to help her and others, we decided to establish AlphaPerrin Computational, LLC.
Conducting computational chemistry before in vitro chemistry is a tremendous advantage. It is not only exponentially cheaper, but also more efficient, providing faster results. This preliminary computational work offers insights into the feasibility of subsequent in vitro experiments.
AlphaPerrin Computational has been undergoing beta testing for two years to resolve any potential issues clients might encounter while conducting in silico experiments. We are now ready to accept customers. By filling out the contact form, you will be contacted by us to discuss your experimental needs and objectives. We look forward to hearing from you!
Dr Noah Allen
Our Service
Self- Service Labs
Experience our Self-Service in silico Laboratory, designed for your convenience, offering customized access to our state-of-the-art systems. Enjoy the freedom to utilize our resources on your terms, empowering you to conduct experiments, analysis, and research with efficiency and effectiveness in your personal laboratory space. Utilize this innovative platform to accelerate drug discovery efforts and drive advancements in pharmaceutical research.
Privacy and Security
Explore our Self-Service in silico Laboratory, where your data and usage remain entirely private. Rest assured, all your information is safeguarded by a non-disclosure agreement under all circumstances. This ensures confidentiality and security while you leverage our cutting-edge systems for experiments, analysis, and research tailored to your needs. Enjoy the flexibility of conducting your work with peace of mind in your dedicated laboratory space.
Reliability and Redundancy
Discover our Self-Service in silico Laboratory, where reliability is paramount. Our platform boasts redundant systems that are continuously backed up to prevent any potential errors in communication with our servers. This ensures seamless connectivity and uninterrupted access to our cutting-edge resources as you conduct experiments, analysis, and research. Enjoy the peace of mind that comes with our robust infrastructure, designed to support your work with utmost reliability.
Service Assurance Agreement
Upon joining Alphaperrin Computational, LLC, you’ll receive a comprehensive service agreement outlining the precise services you’ll receive. This agreement remains active throughout your tenure as our valued customer. It ensures clarity regarding the scope of services rendered and provides assurance of our commitment to meeting your needs effectively and consistently over time.